IVF treatments for the most severe forms of infertility
in males are associated
with an increased risk of intellectual disability and autism in children.
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| IVF Treatment |
The study is the
largest of its kind and was led by researchers at King's College London (UK),
Karolinska Institutet (Sweden) and Mount Sinai School of Medicine in New York
(USA).
By using anonymous data from the Swedish national registers, researchers analysed more than 2.5 million birth records from 1982 and 2007 and followed-up whether children had a clinical diagnosis of autism or intellectual disability (defined as having an IQ below 70) up until 2009.
By using anonymous data from the Swedish national registers, researchers analysed more than 2.5 million birth records from 1982 and 2007 and followed-up whether children had a clinical diagnosis of autism or intellectual disability (defined as having an IQ below 70) up until 2009.
Autism and
intellectual disability remain a rare outcome of IVF, and whilst some of the
risk is associated with the risk of multiple births, the study provides
important evidence for parents and clinicians on the relative risks of modern
IVF treatments.
Of the 2.5m children,
1.2 percent (30,959) were born following IVF. Of the 6,959 diagnosed with
autism, 103 were born after IVF; of the 15,830 with intellectual disability,
180 were born after IVF.
Multiple pregnancies are a known risk factor for pre-term birth and some neurodevelopmental disorders, so the researchers also compared single to multiple births.
Sven Sandin, co-author of the study from King's College London's Institute of Psychiatry said, "IVF treatments are vastly different in terms of their complexity. When we looked at IVF treatments combined, we found there was no overall increased risk for autism, but a small increased risk of intellectual disability. When we separated the different IVF treatments, we found that 'traditional' IVF is safe, but that IVF involving ICSI, which is specifically recommended for paternal infertility is associated with an increased risk of both intellectual disability and autism in children."
Compared to spontaneous conception, children born from any IVF treatment were not at an increased risk of autism, but were at a small increased risk of intellectual disability (18 percent increase - from 39.8 to 46.3 per 100,000 person years).
However, the risk increase disappeared when multiple births were taken into account.
Secondly, the researchers compared all 6 different types of IVF procedures available in Sweden - whether fresh or frozen embryos were used; if intracytoplasmic sperm injection (ICSI) was used, and if so, whether sperm was ejaculated or surgically extracted.
Developed in 1992, ICSI is recommended for male infertility and is now used in about half of all IVF treatments.
The procedure involves injecting a single sperm directly into an egg, rather than fertilization happening in a dish, as in standard IVF.
Children born after IVF treatments with ICSI (with either fresh or frozen embryos) were at an increased risk of intellectual disability (51 percent increase - 62 to 93 per 100,000).
Multiple pregnancies are a known risk factor for pre-term birth and some neurodevelopmental disorders, so the researchers also compared single to multiple births.
Sven Sandin, co-author of the study from King's College London's Institute of Psychiatry said, "IVF treatments are vastly different in terms of their complexity. When we looked at IVF treatments combined, we found there was no overall increased risk for autism, but a small increased risk of intellectual disability. When we separated the different IVF treatments, we found that 'traditional' IVF is safe, but that IVF involving ICSI, which is specifically recommended for paternal infertility is associated with an increased risk of both intellectual disability and autism in children."
Compared to spontaneous conception, children born from any IVF treatment were not at an increased risk of autism, but were at a small increased risk of intellectual disability (18 percent increase - from 39.8 to 46.3 per 100,000 person years).
However, the risk increase disappeared when multiple births were taken into account.
Secondly, the researchers compared all 6 different types of IVF procedures available in Sweden - whether fresh or frozen embryos were used; if intracytoplasmic sperm injection (ICSI) was used, and if so, whether sperm was ejaculated or surgically extracted.
Developed in 1992, ICSI is recommended for male infertility and is now used in about half of all IVF treatments.
The procedure involves injecting a single sperm directly into an egg, rather than fertilization happening in a dish, as in standard IVF.
Children born after IVF treatments with ICSI (with either fresh or frozen embryos) were at an increased risk of intellectual disability (51 percent increase - 62 to 93 per 100,000).